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Hydration status significantly affects periorbital appearance with dehydration exaggerating dark circles through increased blood viscosity pooling more visibly, skin dullness from reduced cellular hydration making circles more prominent, and impaired lymphatic function allowing fluid retention despite overall dehydration

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Eur J Clin Nutr 72, 105111.CrossRefGoogle ScholarPubMed Gandek, TB, van der Koog, L & Nagelkerke, A (2023) A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles