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Notably, crosstalk between other forms of PCD and ferroptosis has been indicated by certain studies during RPE cell death

DPP9 stabilizes NRF2 to suppress ferroptosis and induce sorafenib resistance in clear cell renal cell carcinoma

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We hypothesized that the proteome of the viruses should preferentially interact with enzymes relevant to their replication without harming cellular viability and hence, be considered tier-1 targets