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10.1016/j.phytol.2015.09.003 Rev

Hunger increases, fullness becomes less reliable, and metabolic adaptation makes maintenance difficult

Back Tschp, MH, Finan, B, Clemmensen, C, et al (July 2016) 'Unimolecular polypharmacy for treatment of diabetes and obesity', Cell Metabolism , 24, 51-62

Higher insulin levels promote weight gain and metabolic stress, while low portal insulin and high glucagon tend to produce post-meal hyperglycaemia and increased insulin requirements