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Altogether, muscle loss during GLP1RAs therapy is multifactorial, involving reduced protein intake and negative energy balance, hormonal adaptations, impaired mTOR signaling and protein synthesis, increased proteolysis and potential mitochondrial adaptations, and age, frailty, and physical inactivity as modifiers (Fig

Weight loss: GLP-1s like Tirzepatide are also approved for weight loss in individuals without diabetes

Novo Nordisk plans to file for regulatory approval in the U.S

Some exploratory brain imaging findings suggested potential benefits in reducing glucose metabolism decline in certain brain regions, but these were secondary outcomes requiring further investigation