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firstly, the accumulation of AGEs engages their receptor RAGE on macrophages, initiating robust pro-inflammatory signaling cascades such as the NF-B pathway, which transcriptionally upregulates key M1 markers (e.g., TNF-, IL-6, iNOS) while suppressing M2-associated genes like Arg1 (Dong et al., 2016
This premium Urolithin A supports mitochondrial health, enhances energy, and improves performance
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