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Indeed, in contrast to the rodent, we have been unable to confirm that excess prepubertal androgens result in a diminutive penis in children with congenital adrenal hyperplasia14 or in children with micropenis secondary to the vanishing testis syndrome treated with prepubertal androgens.15 Because of the substantial difference in penile anatomy, penile androgen receptor expression, and the inability to correlate rodent to human data, we currently believe that the rodent animal model for micropenis may not truly reflect the nature of the human disease process

P value in bold is statistically significant