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NevolaRRaffaella EpifaniImbrianiSTortorellaGApreaCRaffaele Galieroet al

R.Boughton-SmithN

Experimental evidence in rats and mice highlights the neuroprotective potential of GLP-1 medicines, primarily through anti-inflammatory and cytoprotective mechanisms 13 and via metabolic improvements in the CNS (Figure 1)

476 The expression of NAMPT is closely related to the expression of pro-inflammatory cytokines in the inflammation induced by free fatty acids and is remarkably reduced by the inhibition of NF-B in HepG2 cells