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Given that more than 7500 genetic disorders and 290,000 disease-causing mutations are cataloged in the OMIM and HGMD databases, it is not feasible to develop clinical-grade vectors for each specific mutation

doi: 10.1371/journal.pone.0014157 28 HamoudaneMMaffioliSCorderaRMaggiDSalaniB

Combined with the D+Q associated reduction in ventricle size as assessed by MRI, a surrogate measure of neurodegeneration, the data suggested that clearing senescent cells was beneficial for neuronal preservation