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Keywords: Weight Loss, Lipid Metabolism, Ketone Bodies, Caloric Restriction, Body Composition Introduction Calorie restriction (CR), a reduction in caloric intake without malnutrition, has consistently been found to produce reductions in body weight and extend healthy life span across a variety of species,(1) including non-human primates.(2) Studies conducted in overweight humans indicate short-term CR (6-months) can significantly improve several cardiovascular risk factors, insulin-sensitivity, and mitochondrial function.(3) Thus, there is emerging evidence from human clinical trials to indicate in overweight adults, CR may have a number of beneficial effects, in addition to weight loss

Treatment with buprenorphine has been shown to reduce all-cause mortality in patients with opioid use disorder

Li Z, Wang F, Liang B, Su Y, Sun S, Xia S, Shao J, Zhang Z, Hong M, Zhang F, Zheng S