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To think about why that is, lets first consider an analogy

Some improvements were noted in specific symptoms for female participants, particularly in reducing thirst and fatigue, but these effects were not significant across the broader participant group

In astudyconducted on adult female rats, different doses of Ipamorelin (0, 18, 90, and 450 microg/day) were administered three times a day for 15 days to investigate its effects on longitudinal bone growth rate (LGR), body weight (BW), and GH release

I am pretty sure it has a lot to do with taking the week off but more then likely also with increased volume for eccentric loading and cross friction massage