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14,421 Views 101 Download 39 Crossref ABSTRACT Glucagon-like peptide 1 (GLP-1) is secreted from enteroendocrine L-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion

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Previous solution-phase studies and computational models of GLP-1 and exendin-4 indicated that the N-terminal had a type II beta turn, but more recent results concluded that the secondary structure of peptides, when bound to class B GPCRs of which the GLP-1R is one, is helical all through the sequence (41)