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WL contributed to the acquisition, analysis, and interpretation of data in this manuscript

Furthermore, data showing whether 'responders' had lower baseline concentrations of GSH or GSH:GSSG were not provided

Glutathione works through several mechanisms: The thiol group directly neutralizes free radicals It helps regenerate other essential antioxidants like vitamins C and E It binds with toxins to make them water-soluble for elimination It helps repair DNA damage through enzyme systems This molecular powerhouse balances production, consumption, and recycling to ensure our cells stay protected

iFSP1 is less efficient than the genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background has no additive effect on RSL3-induced ferroptosis