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For example, liraglutide (LEADER trial), injectable semaglutide (SUSTAIN-6), dulaglutide (REWIND), and high-dose semaglutide (SELECT) have shown cardiovascular risk reduction in their respective clinical trials

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Nonetheless, an increasing body of research substantiates the efficacy of herbal antidepressants as promising adjuncts or alternatives to pharmacotherapy, with the potential to enhance treatment outcomes through converging biological mechanisms

Hypersensitivity reactions Severe allergic reactions are documented, presenting variously with rash, urticaria, angioedema, and anaphylaxis