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They increase glucose uptake and utilization and improve cardiac metabolism, as well as left ventricular function36,41

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Within this mechanistic framework, natural compounds with antioxidant and anti-inflammatory properties, including vitamins C and E, glutathione precursors, CoQ10, L-carnosine, polyphenols including quercetin, resveratrol, and curcumin, and saffron metabolites like crocin and safranal show biological plausibility and preliminary efficacy on biochemical and behavioral endpoints

Nevertheless, major small-molecule drugs used for cancer therapy act by suppressing protein activity