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Female mice lacking PPAR/ show reduced expression of complement component 1qb (C1qb) and other opsonins, which impairs the clearance of apoptotic cells and reduces the production of anti-inflammatory cytokines, making these mice more susceptible to autoimmune kidney disease [300]

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Activation of the GLP-1 receptor in microglia, GABAergic interneurons and astrocytes stimulates several intracellular pathways including the PI3K/Akt, cAMP/PKA/CREB, and P-Akt/p-eNOS and subsequently confers neuroprotective effects through inhibition of gp91/CHOP, Nrf2/HO-1, Bax/Bcl-2/caspase3/PARP, NF-B/ICAM-1, and JAK2/STAT3

Yes, semaglutide has received approval from health authorities in some regions for weight management in individuals without diabetes