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Is it possible we are missing a treatment effect of Lixisenatide because of the heterogeneity present in most Parkinsons groups recruited for clinical trials (in other words Parkinsons is not one disease and we may have recruited a few different subtypes and this watered down the potential effects)

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Thus, there may be reduced translational potential of some rodent metabolic studies and further research will need to focus on model systems more aligned with human metabolic rates, e.g., resected human cortex or organoid models (Westi et al., 2022

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