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Visualization of the PCs (bi-plots) demonstrated that PC2 (17 analytes, 17.1% variability explained) exhibited the greatest separation between groups

These injectable therapies are sensitive to temperature and light, and even minor mistakes in handling can reduce their effectiveness

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In preclinical efficacy studies in diet-induced obese (DIO) mice and obese monkeys, treatment with AMG133 reduces body weight and improves metabolic parameters to a larger extent than a GLP-1 receptor agonist alone (84), while, at this time, phase 2 data have only been disclosed through a company announcement with headline results (85)