glp 1 alcohol use disorder One enzyme could be behind addiction and liver disease GLP-1 Receptor Agonists: Promising Therapeutic

Bertholet-Thomas A, Claramunt-Taberner D, Gaillard S, Deschenes G, Sornay-Rendu E, Szulc P, Cohen-Solal M, Pelletier S, Carlier MC, Cochat P, Bacchetta J (2018) Teenagers and young adults with nephropathic cystinosis display significant bone disease and cortical impairment

It acts by inhibiting mitochondrial complex I, which reduces ATP production, which results in compensatory upregulation of glycolysis, secondary lactate production, and oxidative stress [434]

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Nat Commun 5:5338 Cai Q, Chen M, Wang B, Wang J, Xia L, Li J (2024) Inhibition of lung adenocarcinoma cell growth by phytosphingosine inducing G2/M-phase arrest, apoptosis, and mitochondria-dependent pathway cell death in vitro and in vivo