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It also signals underlying triggers hormonal imbalance, chronic inflammation, or sun damage that are worth addressing holistically, not just topically

NIA P01AG021654, P30AG038072, R37AG18381 and the Paul Glenn Foundation for Medical Research to N.B

"Unlike plaques, oxidative stress is difficult to see down a microscope, so the theory has always been at a disadvantage psychologically in terms of popularity in the field