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For example, low-dose bortezomib induces autophagy and reduces mutant huntingtin aggregation in HD models

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doi:10.1155/2015/760689 Morrison CD, Reed SD, Henagan TM

Advantage: Convenient, familiar, non-invasive Challenge: Peptides face proteolytic degradation in the stomach and small intestine Bioavailability: Estimated at approximately 38% based on comparative pharmacology (see below) Transdermal (Patch) Some researchers have explored transdermal patches to deliver peptides: Advantage: Avoids first-pass metabolism and GI degradation Challenge: Intact skin is a strong barrier to peptide penetration Feasibility: Not commonly available commercially