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3.6 Melanogenesis reduction Ultraviolet radiation stimulates melanogenesis through activation of the microphthalmia-associated transcription factor (MITF)-regulated pathway, promoting tyrosinase (TYR)-dependent melanin synthesis in melanosomes to protect against DNA damage, while excessive production leads to hyperpigmentation disorders (Kim et al., 2021)

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If elevated ROS and/or lower antioxidant activities are responsible for the damage done to gametes and embryos incubated in PF and FF of endometriosis patients, then the addition of antioxidants to PF and FF incubation medium should decrease rates of gamete and embryo damage

Canadian residents can typically purchase research peptides from domestic and international suppliers without legal issues