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Cibinetide (ARA-290): A More Preventative, Balanced Anti-Inflammatory Approach In contrast, cibinetide (ARA-290), when given systemically (typically via subcutaneous injection), circulates and reduces inflammation more directly through selective activation of the innate repair receptor (IRR) a heterocomplex (EPOR/-common receptor or CD131) that is upregulated primarily on cells in response to tissue injury, hypoxia, metabolic stress, or inflammation

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Eur J Nutr 61(8):38353855 Zhang X, Zhong Y, Rajabi S (2025) Polyphenols and post-exercise muscle damage: a comprehensive review of literature