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Briefly, this axis i) involves gut microbial metabolites and the host co-metabolites derived from phenylalanine and tyrosine metabolism, ii) is supported by genetic evidence indicating an interaction between the gut microbiome and kidney function of the host, the functional associations of which are depleted in the MetaCardis cases with CMD ( n = 1602), and iii) associates with future CVD incidence in the participants of the Canadian Longitudinal Study on Aging (CLSA) study (n = 8,669)

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