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258 In contrast, the reduction of mitochondrial NAD + levels inhibits SIRT3 activity, increasing ROS levels through the deactivation of superoxide dismutase 2 (SOD2), facilitating the metastasis of hepatocellular carcinoma cells

61,103,270,282 Uric acid diminishes nitric oxide levels through several mechanisms, including the consumption of NO due to excessive reactive oxygen species production and direct inhibition of NO synthesis

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A poorly stored vial is an under-dosed vial