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Journal of Immunology , 1999

Despite these challenges, new therapies based on elucidated genes have been developed in recent years, such as gene replacement, gene editing and translating oligonucleotides

17,18 More importantly, existing ecological niche remodeling strategies, such as broad-spectrum probiotics, prebiotics, or FMT, exhibit significant individual differences and uncertainty in efficacy and may even produce harmful results, highlighting the urgent necessity of shifting from broad-spectrum interventions to precision targeting