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What the research shows: Frye et al., 2016: 48 children with autism + language impairment received leucovorin (0.52 mg/kg/day, up to 50 mg/day) for 12 weeks

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This seemingly small chemical modification brings profound functional changes: the acetylated thiol group is protected from oxidation and enzymatic breakdown, while the overall molecules lipophilicity is significantly enhanced, allowing it to cross biological membranes more easily

Enko D, Zelzer S, Niedrist T, et al