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Exclusion criteria : Any condition that may influence the patients ability to comply with study protocol Contraindications for beta-blockade Indication for beta-blockade other than as secondary prevention according to the treating physician Randomization: 1:1 according to trial center Assigned by a Web-based system Beta-blocker group: Metoprolol (first choice) or bisoprolol (alternative) during the remaining hospital stay and received a prescription for continued use after discharge

doi: 10.3389/fendo.2022.877807

Most side effects are mild to moderate and tend to diminish as the body adjusts

Further information from clinical trials and continued research would be necessary to make a more precise determination of how CT-PYY might become part of the PWS treatment paradigm