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Chronic diseases often have immune dysfunction

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5,6 For example, free radicals play a role in detoxification of xenobiotics by oxidizing enzymes, in killing of microorganisms by macrophages and cytotoxic lymphocytes, and in the generation of prostaglandins and leukotrienes, which activate oxygenases (e.g., cyclooxygenases and lipoxygenase) and thus act as modulators of the inflammatory response