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IPA restores LGR5 + ISCs and enhances epithelial regeneration in colitis by activating IEC ketogenesis To elucidate how IPA regulates mucosal barrier function, we performed RNA-sequencing (RNA-seq) analysis of bulk colonic intestinal epithelial cells (cIECs) isolated from IPA-treated and nontreated mice at D0, D3 and D7 post-DSS administration (Supplementary Fig

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