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The results showed that a genetic variant in the GRIK2 gene was more common in people with ME/CFS, and that the gene expression for that gene was decreased by 10-fold in patients compared to controls.[ref] Related article: Glutamate receptor gene variants Circadian clock gene, NPAS2: The study mentioned above also identified a circadian clock gene variant as differentially expressed (10-fold difference) and a variant in the gene as increasing susceptibility to ME/CFS.[ref] Rare mutations: A 2025 Stanford study using the HEAL2 deep learning framework analyzed whole genome sequences from 1,075 ME/CFS patients

Moiz and colleagues acknowledged some study limitations