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The 50 and 130 kDa low-molecular-weight forms specifically produced significant wrinkle-depth reduction by mean roughness (Ra) and maximum roughness (Rz) measurement, attributed to deeper dermal penetration of the smaller molecules [7]

Throughout much of their range they are known as Bhos de Anteojos , Tecolotes de Anteojos , and Lechuzones de Anteojos, which are all direct translations of their English common name

The kidney warnings reflect the potential for indirect effects through volume depletion in susceptible individuals rather than direct nephrotoxicity