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Regular kidney function assessments are recommended, especially for those with pre-existing kidney disease

Because metabolic syndrome is often related to obesity, glucose and lipid metabolism have been extensively researched in obese subjects

It has been observed that chronic treatment with KI in rats results in the loss of spermatogenesis, decreased activities of enzymes participating in testosterone production, structural and functional changes of the testis, all these abnormalities being accompanied by the increased oxidative stress [186, 187]

First, it was reported that the mechanism of C-cell transformation in rodents is by activation of the GLP-1 receptor on the C cell, and a study has shown that GLP-1 receptor stimulation is a better predictor of C-cell hyperplasia than plasma drug concentrations of exenatide and liraglutide (69)