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J Clin Endocrinol Metab 88(4):17721779

Table 2: Variation of regional brain metabolite levels with diagnosis group, age, and sex as fixed effects in robust linear mixed-effects (LME) models

The STEP 1 trial, published in the New England Journal of Medicine in 2021, showed that participants taking semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group