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It has been shown that SIRT1 and SIRT1 activators reduce the risk of PD in MPTP-model mice through the suppression of pro-apoptotic and apoptotic pathways (Calopa et al

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While the serum concentration of cobalamin is used diagnostically, the reactions catalyzed by cobalamin dependent enzymes occur in the mitochondria, making it difficult to assess the state of cobalamin availability in the patient