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Its detected by: - Increased serum creatinine (always compare with baseline creatinine!) - Decreased urine output Causes of AKI Pre-renal (most common): Inadequate perfusion - Kidneys are intact but starved of blood Causes: dehydration, blood loss, sepsis, heart failure Intrarenal: Direct damage to kidney tissue - can occur after prolonged pre-renal AKI Causes: Nephrotoxic medications (e.g