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Supercooling prevents the accumulation of free fatty acids and consumption of acyl-carnitines Storage-induced and oxidant stress-dependent activation of phospholipase A2 (PLA2) or PLA2-like enzymes such as peroxiredoxin 6 50,51 has been observed during RBC storage and represents a hallmark of storage-induced lipid peroxidation (Fig

The 86% decrease in liver fat observed with the highest dose is one of the best reported to date

At present, the lack of large-scale, confirmatory clinical trials specifically targeting MC4R deficiency is largely due to significant scientific and clinical heterogeneity, which has made conducting such trials logistically challenging and commercially less appealing compared to pursuing broader or more clearly defined patient populations