While preclinical studies, primarily in animal models 17,18 , suggest a potential beneficial effect of GLP-1 RAs on mood and behavior, the clinical evidence in humans remains unclear 19,20
The most important rule is to start low and go slow
Quick Summary GLP-1 medications reduce appetite, which makes consistent nutrient intake harder over time A multivitamin, protein support, electrolytes, and targeted nutrients form the foundation of a balanced GLP-1 supplement routine Protein is the most important nutrient to prioritize, especially for muscle maintenance and energy Hydration and electrolyte support are commonly overlooked but essential Simple, repeatable routines work better than complex supplement stacks Most GLP-1 users benefit from supporting nutrition with structured supplementation Who This Guide Is For This guide is designed for: Ozempic users Wegovy users Semaglutide users Anyone building a daily supplement routine on GLP-1 medications Why Supplements Matter on GLP-1 Medications GLP-1 medications work by slowing digestion and reducing appetite
Nauck MA, Muus Ghorbani ML, Kreiner E, Saevereid HA, Buse JB, LEADER Publication Committee on behalf of the LEADER Trial Investigators
