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Its not a medication, and its not approved for human or animal use outside of authorized studies 5-Amino-1MQ is a small-molecule research compound supplied for in-vitro investigation into metabolic and enzymatic signaling pathways, particularly through its activity as an inhibitor of nicotinamide N-methyltransferase (NNMT)

Methionine is also helpful in preventing fatigue and may be useful in some cases of allergies as it can reduce histamine release

As well, once you get to stage 4 deficiency you can get macrocytic anemia

[DOI] [PubMed] [Google Scholar] 68.Gianella P., Pietra M., Crisi P.E., Bergamini P.F., Fracassi F., Morini M., Boari A