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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: April 5, 2026 The short answer is that long-term Melanotan use carries significant uncertainties because the synthetic peptide is not FDA-approved, and no rigorous clinical trials have studied its extended safety profile

The 61-year-old company is initiating a business and brand transformation, rethinking its positioning in a weight loss market upended by the rise of GLP-1 anti-obesity drugs including Ozempic