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Lancet 402 , 16031606 (2023)

If your skin reacts more than it used to, breaks out after pollution exposure, or feels generally more sensitive, declining antioxidant levels may be a contributing factor

It has been reported that silencing of PTEN cooperates with activated AKT to promote metastasis of melanoma (102, 103, 106, 107), but MM does not show a weaker performance in metastasis than CM in the clinic possibly because there are other gene alterations in the PI3K pathway promoting invasiveness of tumor (108)