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Metformin has been shown to be associated with a decreased death risk, improved clinical outcomes, and delayed progression to ESRD in patients with DKD ( in vitro and vivo have shown that metformin attenuates the progression of DKD by suppressing renal inflammation, oxidative stress, and fibrosis ( in vitro upon high glucose exposure ( In conclusion, metformin could ameliorate inflammation and oxidative stress in renal tubular cells, regulate apoptosis and autophagy, and attenuate tubulointerstitial damage through various mechanisms

Pain 163 , e738e747 (2022)

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