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Measuring kinase mRNA expression with a gene chip in rats treated with a 3-day or 21-day courses of fluoxetine, specific pkc isoforms prkcg and prkcd were found to be increased after 3 days and decreased after 21 days of fluoxetine administration (Rausch et al., 2002)

This is exactly what you see on the y-axis in the figure above (Intravenous bioavailability)

Main methods Assessment included magnesium sulfate (560 mg/kg intraperitoneally)-induced muscle weakness, muscle and brain lesions, hypermagnesemia, hyperkalaemia, increased serum enzyme values assessed in rats during and at the end of a 30-min period and medication (given intraperitoneally/kg at 15 min before magnesium) [BPC 157 (10 g, 10 ng), l-NAME (5 mg), l-arginine (100 mg), alone and/or together]

Ensuring adequate electrolyte intake matters too, since peptide protocols sometimes coincide with dietary changes that affect mineral balance