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Collectively, these data support that mitochondrial dynamics and function are impaired by ketamine or sevoflurane exposure and iron chelation may ameliorate the injury

But this does not substitute for controlled trials, and patients should understand they are, in effect, early adopters of an approach that is not yet evidence-based in the traditional sense

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Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate