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While injections deliver medicine directly into the patients bloodstream, a pills medicine is absorbed through the digestive system, which can be slower and less effective

This effect doesnt mean the medication isnt working it reflects the natural pharmacokinetics of semaglutide and individual variability in how quickly the drug is metabolized and cleared

The increase in use of GLP-1s is alarming for two reasons: (1) The first reason that the increase in use of GLP-1 drugs is concerning is their little-known long-term side effects and potentially unknown short-term side effects

Effects appear more consistent with higher doses (10 billion CFU/day), longer duration (812 weeks), and in individuals with obesity