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Undetected vitamin B12 deficiency due to false normal assay ...ncbi.nlm.nih.gov articles PMC3827408 by E Scarpa 2013 Cited by 25 Although measurement of vitamin B12 levels is the gold standard for the diagnosis of B12 deficiency some reports do exist concerning difficulties in its assay

They are particularly beneficial for individuals with absorption issues, long-term fatigue, anaemia, or medically confirmed deficiency

Half-life & zero-order kinetics : Phenytoins metabolism is saturable , resulting in zero-order kinetics (a fixed amount of the drug is cleared regardless of the drug level)

Over time, laboratory studies began to investigate its theoretical benefits on musculoskeletal and neural tissues