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Activated Rheb subsequently activates mTORC1 (87), promoting mRNA translation by releasing the inhibition on eIF4E (88) and stimulating protein synthesis via the phosphorylation of ribosomal protein S6 (89)

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They control hyperglycemia and prevent diabetic complications (reducing risk factors, e.g., OS and obesity) by improving insulin sensitivity, as confirmed in vivo and in humans [[40], [41], [42], [45], [46]]