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What the Trials Say About Headache Rates with Mounjaro and Zepbound Clinical trial data indicate a dose relationship for many side effects of tirzepatide, and headache numbers follow this pattern in several studies

The American Association of Endocrinologists and American College of Endocrinology's recommendations list GLP-1 receptor agonists as the preferred add-on to metformin, followed by SGLT2 inhibitors and DPP-4 inhibitors as preferred oral add-on options

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