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For patients switching from insurance to direct-pay or those uninsured from the start, this cost difference translates to $8,000-$12,000 in annual savingsfunds that can be redirected toward diet, fitness, or long-term weight maintenance programs

The anti-inflammatory and neuroprotective properties of GLP-1s, along with their metabolic effects, make them ideal candidates for these multifactorial diseases

383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)

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