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For the survival cohort study, Rosa26-creERT2 ;Gpx4 f/f mice were intraperitoneally treated with tamoxifen (Sigma-Aldrich, T2859, 2 mg per day dissolved in Myglyol 812) on days 0 and 1 for deletion of Gpx4 in the whole body except in the brain 2

Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit

J Med Plants Rese

The incidence of renal dysfunction is related to the severity of the acetaminophen ingestion * : Patients with liver involvement but no hepatic failure: ~5% Patients with severe poisoning:10% Patients with acute hepatic failure: ~50% Pathogenesis * Direct toxicity by toxic metabolites of APAP, oxidized by CYP in the kidney