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With intestinal disease (including bypass operations that may be performed to treat obesity), increased fecal loss of bile acids leads to decreased concentrations of both primary and secondary bile acids and, often, a decrease in cholesterol caused by increased need for bile acid synthesis

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For example, 2.5-micron particulate matter is an environmental pollutant that has been demonstrated to induce iron overload and lipid peroxidation, leading to male reproductive dysfunction [83, 110]

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